Publications

Muruganandan S., Pierce R., Teguh D.A., Perez R.F., Bell, Nguyen B., Hohl K., Snyder B.D., Grinstaff M.W., Alberico H., Woods D., Kong Y., Sima C., Bhagat S., Ho K., Rosen V., Gamer L., Ionescu A.M. (2022) A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury. Nature Communications, May 6; 13(1): 2515, https://doi.org/10.1038/s41467-022-30247-1, PMID: 35523895

Bell N., Bhagat S., Muruganandan S., Kim R., Ho K., Pierce R., Kozhemyakina E., Lassar A.B., Gamer L., Rosen V., Ionescu A.M. (2022) Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the hypertrophic zone at the expense of the primary ossification center formation. Bone. Apr 6;160:116418. doi: 10.1016/j.bone.2022.116418. Online ahead of print. PMID: 35398294 

Maridas D.E, Gamer L., Moore E., Doedens A.M., Yu Y., Ionescu A.M, Revollo L., Whitman M., Rosen V. (2022) Loss of Vlk in Prx1+ cells delays the initial steps of endochondral bone formation and fracture repair in the limb. J Bone Miner Res, 37(4):764-775 PMID: 35080046

Revollo L.D., Merrill-Skoloff G., De Ceunynck K., Dilks J.R., Guo S., Bordoli MR, Peters CG, Noetzli L, Ionescu AM, Rosen V, Italiano JE, Whitman M, Flaumenhaft R (2022). The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation. Blood. 139(1): 104-117 PMID: 34329392

Muruganandan S., Ionescu A.M., Sinal C.J. (2020) At the crossroads of the adipocyte and osteoclast differentiation programs: Future therapeutic perspectives.  International Journal of Molecular Sciences. Mar26; 21(7):2277, PMID: 32224846

Gamer LW, Pregizer S, Gamer J, Feigenson M, Ionescu A, Li Q, Han L, Rosen V. (2018) The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint J Bone Miner Res. 33(9):1708-1717. PMID: 29665134

Kozhemyakina E, Zhang M, Ionescu A, Ayturk UM, Ono N, Kobayashi A, Kronenberg H, Warman ML, Lassar AB (2015). Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol. 67(5):1261-73. PMID: 25603997

Daoud G., Kempf H., Kumar D., Kozhemyakina E., Holowacz T., Kim D., Ionescu A.M., Lassar A.B. (2014) BMP-mediated induction of GATA4/5/6 blocks somatic responsiveness to SHH. Development. 141(20): 3978-87. PMID: 25294942

Kozhemyakina E., Ionescu A.M. and Andrew B. Lassar (2014) GATA6 is a crucial regulator of Shh signaling in the limb bud. PLOS Genetics. 10(1):e1004072. PMID: 24415953

Ionescu A.M, Kozhemyakina E., Nicolae C., Kaestner K.H., Olsen B.R., Lassar A.B. (2012) FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Developmental Cell 22(5):927-39. PMID: 22595668

Kempf H., Ionescu A.M., Udager A, Lassar A.B. (2007) Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expression. Developmental Dynamics. 236(7):1954-62. PMID: 17576141

Li TF, Zuscik MJ, Ionescu A.M., Zhang X, Rosier RN, Schwarz EM, Drissi H, O’Keefe RJ. (2004) PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Experimental Cell Research 300(1):159-69. PMID: 15383323

Li T.F., Dong Y., Ionescu A.M., Rosier R.N., Zuscik M.J., Schwarz E.M., O’Keefe R.J., Drissi H (2004) Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Experimental Cell Research 299(1):128-36. PMID: 15302580

Ionescu A.M., Drissi M.H., Schwarz E.M., Kato M., Puzas J.E., McCance D.J., Rosier R.N., Zuscik M.J., O’Keefe R.J. (2004). CREB cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter Journal of Cellular Physiology 198(3):428-440. PMID: 14755548

Ionescu A.M., Schwarz E.M., Zuscik M.J., Drissi H., Puzas J.E., Rosier R.N., O’Keefe R.J. (2003) ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Experimental Cell Research 288 (1): 198-207. PMID: 12878171

Li X., Schwarz E.M., Zuscik M.J., Rosier R.N., Ionescu A.M., Puzas J.E., Drissi H., Sheu T.J. and O’Keefe R.J. (2003). Retinoic acid stimulates chondrocyte differentiation and enhances Bone Morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 144(6): 2514-23. PMID: 12746314

Li X., Ionescu A.M., Schwarz E.M., Zhang X., Drissi H., Puzas J.E., Rosier R.N., Zuscik M.J., and O’Keefe R.J. (2003). Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. Journal of Orthopaedic Research. 21(5): 908-13. PMID: 12919880

Zuscik M.J., D’Souza M., Ionescu A.M., Gunter K.K., Gunter T.E., O’Keefe R.J., Schwarz E.M., Puzas J.E., Rosier R.N. (2002). Growth plate chondrocyte maturation is regulated by basal intracellular calcium. [erratum appears in Exp Cell Res 2002 Jul 15;277(2):233]. Experimental Cell Research. 276(2): 310-9. PMID: 12027460

Pateder D.B., Ferguson C.M., Ionescu A.M., Schwarz E.M., Rosier R.N., Puzas J.E., O’Keefe R.J. (2001). PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling. Journal of Cellular Physiology. 188(3): 343-51. PMID: 11473361

Ionescu A.M., Schwarz E.M., Vinson C., Rosier R.N., Reynolds P.R., O’Keefe R.J. (2001). PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. Journal of Biological Chemistry. 276(15): 11639-47. PMID: 11136722